Compared to Arch(-based): Accesing the latest packages. It’s not impossible, especially if you go for Debian testing repos, but it’s definitely extra work.
Compared to special-purpose distros (i.e. gaming, portable, high security/privacy, pen-testing): Whatever their special purpose is will usually be harder to achieve.
Compared to huge corpo distros (SUSE/Fedora and derivatives): Ease of more intricate setups and maybe some security testing.
Compared to Ubuntu: Paying a corporation to not withhold security patches from you.
Tbf, you could use portable / user installs (if everyone would actually do their apps right), you can (now) use a package manager and you can (sometimes…) get an official, verified version of an app through the store and even if not, installers are (usually…) signed these days (although criminals do apparently get signatures too…)… And then this all falls apart, because you need a random driver from a random website. Security 👉👉