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Not particularly, the workflow on your Arch system will be the same as any other distro, that’s the nice thing about Distrobox.
I would highly recommend looking into the distrobox-assemble
command, though: it lets you declaratively build distroboxes with the packages and config you need on them. I have a personal box which operates as my primary terminal that’s automatically destroyed and recreated on every boot. This way, the packages I always use in a terminal are available, and I can add something I need temporarily with no issue without worrying about forgetting about that package being there down the line and causing some weird update failure or general bloat.
https://github.com/htrefil/rkvm